HORDB

ID: hor002036
Uniprot ID: Q95336
Protein name: GnRH-associated peptide 2
Gene name: GNRH2
Organism: Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)
Family: GnRH family
Source: animal
Expression: Midbrain.
Disease: NA
Comments: NA
Taxonomy: Tupaia (genus), Tupaiidae (family), Scandentia (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: ASNSPQDPQSALRPPAPSAAQTAHSFRSAALASPEDSVPWEGRTTAGWSLRRKQHLMRTLLSAAGAPRPAAVPIKP
Length: 76
Propeptide: MASSMLGFLLLLLLLMAAHPGPSEAQHWSHGWYPGGKRASNSPQDPQSALRPPAPSAAQTAHSFRSAALASPEDSVPWEGRTTAGWSLRRKQHLMRTLLSAAGAPRPAAVPIKP
Signal peptide: MASSMLGFLLLLLLLMAAHPGPSEA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002036_AF2.pdb

hor002036_ESM.pdb

Mass:	931692	Formula:	C348H558N110O104S
Absent amino acids:	CY	Common amino acids:	A
pI:	12.13	Basic residues:	11
Polar residues:	18	Hydrophobic residues:	27
Hydrophobicity:	-54.21	Boman Index:	-14652
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.29
Instability Index:	8381.45	Extinction Coefficient cystines:	11000
Absorbance 280nm:	146.67